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Mutation Information
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Mutation Site
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E15A |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
Vpu |
Literature Information
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PubMed PMID
|
32665270
|
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Published Year
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2020 |
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Journal
|
mBio |
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Title
|
Convergent Evolution of HLA-C Downmodulation in HIV-1 and HIV-2. |
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Author
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Hopfensperger K,Richard J,Stürzel CM,Bibollet-Ruche F,Apps R,Leoz M,Plantier JC,Hahn BH,Finzi A,Kirchhoff F,Sauter D |
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Evidence
|
In agreement with previous findings (33, 46), the exchange of 6 amino acids in the transmembrane domain (E15A, T16V, L17S, V19A, I25L, and V26L) was sufficient to confer efficient antitetherin activity to SIVcpz EK505 Vpu (Fig. 4B, top).
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HIV Mutation Detail Information