HIV Mutation Detail Information

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Mutation Information

Mutation Site	E157Q
Mutation Type	Amino acid level
Gene/Protein/Region Type	IN
Relevant Drug	INSTIs
Country	Germany

Literature Information

PubMed PMID	30408827
Disease	HIV infection/AIDS
Published Year	2018
Journal	PloS one
Title	Increasing proportions of HIV-1 non-B subtypes and of NNRTI resistance between 2013 and 2016 in Germany: Results from the national molecular surveillance of new HIV-diagnoses.
Author	Hauser A,Hofmann A,Meixenberger K,Altmann B,Hanke K,Bremer V,Bartmeyer B,Bannert N
Evidence	According to predictions from the Stanford HIVdb, phenotypic INSTI resistance (excluding potential low level) was identified in 0.7% (6/820) of cases (Fig 3B) due to the presence of the T66I (n = 1), the G163R or K (n = 4) or the combination of T97A and E157Q (n = 1) resulting in low level resistance to elvitegravir and raltegravir.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation