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HIV Mutation Detail Information

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Mutation Information
Mutation Site E13K
Mutation Type Amino acid level
Gene/Protein/Region Type IN
Literature Information
PubMed PMID 25383358
Published Year 2014
Journal Molecular therapy. Methods & clinical development
Title Efficient Transduction of LEDGF/p75 Mutant Cells by Gain-of-Function HIV-1 Integrase Mutant Viruses.
Author Wang H,Shun MC,Li X,Di Nunzio F,Hare S,Cherepanov P,Engelman A
Evidence Alteration of LEDGF/p75 residues Lys401, Lys402, and Arg405 to glutamates (K401E/K402E/R405E, referred to as EEE) reduced WT HIV-Luc infection by approximately fivefold, yet boosted the activity of the weakly infectious reverse-charge KK (E10K/E13K) HIV-1 IN mutant virus by approximately sixfold (from ~2% with WT LEDGF/p75 to ~13% with EEE).
Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation