|
Mutation Information
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Mutation Site
|
E138K |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
IN |
|
Genotype/Subtype
|
C |
|
Viral Reference
|
MW690052-MW690089;
MG989443.1;
MG989444.1 |
|
Relevant Drug
|
tenofovir (TDF);emtricitabine (FTC);darunavir (DRV);ritonavir;dolutegravir (DTG);lamivudine (LAM);azidothymidine (AZT);raltegravir (RAL) |
|
Country
|
Botswana |
Literature Information
|
PubMed PMID
|
33807382
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2021 |
|
Journal
|
Viruses |
|
Title
|
HIV-1 Subtype C Drug Resistance Mutations in Heavily Treated Patients Failing Integrase Strand Transfer Inhibitor-Based Regimens in Botswana. |
|
Author
|
Seatla KK,Maruapula D,Choga WT,Ntsipe T,Mathiba N,Mogwele M,Kapanda M,Nkomo B,Ramaabya D,Makhema J,Mmalane M,Mine M,Kasvosve I,Lockman S,Moyo S,Gaseitsiwe S |
|
Evidence
|
Amongst the individuals previously exposed to RAL ART (seven out of eleven), DRMs selected whilst failing their current DTG based regimens were E138K, G140A, Q148R; and N155H Figure 3.
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HIV Mutation Detail Information