|
Mutation Information
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Mutation Site
|
E138K |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
IN |
|
Relevant Drug
|
NNRTIs |
Literature Information
|
PubMed PMID
|
33567378
|
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Published Year
|
2021 |
|
Journal
|
European journal of medicinal chemistry |
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Title
|
Identification of novel potent HIV-1 inhibitors by exploiting the tolerant regions of the NNRTIs binding pocket. |
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Author
|
Sun Y,Kang D,Da F,Zhang T,Li P,Zhang B,De Clercq E,Pannecouque C,Zhan P,Liu X |
|
Evidence
|
Compounds 16a1 and 16b1 turned out to be the most potent inhibitors against WT and mutant HIV-1 strains (L100I, K103N, and E138K), with EC50 values ranging from 0.007 muM to 0.043 muM.
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HIV Mutation Detail Information