HIV Mutation Detail Information

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Mutation Information

Mutation Site	E138K
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT

Literature Information

PubMed PMID	33477685
Published Year	2021
Journal	Viruses
Title	Analysis and Molecular Determinants of HIV RNase H Cleavage Specificity at the PPT/U3 Junction.
Author	Álvarez M,Sapena-Ventura E,Luczkowiak J,Martín-Alonso S,Menéndez-Arias L
Evidence	While preferential cleavage at the G*A site of the PPT/U3 junction was observed with mutants E138K/M184I and E138K/M184V and the WT HIV-1BH10 RT, the presence of N348I/T369I in any of those sequence contexts altered the cleavage preferences and impaired correct processing of the PPT.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation