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Mutation Information
|
Mutation Site
|
E138K |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
IN |
|
Relevant Drug
|
INSTIs |
|
Country
|
Switzerland |
Literature Information
|
PubMed PMID
|
33228206
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2020 |
|
Journal
|
Viruses |
|
Title
|
Emergence of Resistance to Integrase Strand Transfer Inhibitors during Dolutegravir Containing Triple-Therapy in a Treatment-Experienced Patient with Pre-Existing M184V/I Mutation. |
|
Author
|
Braun DL,Scheier T,Ledermann U,Flepp M,Metzner KJ,Böni J,Günthard HF |
|
Evidence
|
This resistance test newly revealed the E138K, Q148R, and R263K INSTI mutations at frequencies of 100% by means of next-generation sequencing (NGS), causing high-level resistance to RAL, EVG, DTG, and BIC.
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HIV Mutation Detail Information