|
Mutation Information
|
Mutation Site
|
E138K |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
IN |
|
Combined Mutation
|
in.S230R+in.E138K |
|
Relevant Drug
|
INSTIs |
|
Country
|
Spain |
Literature Information
|
PubMed PMID
|
32929472
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2020 |
|
Journal
|
The Journal of antimicrobial chemotherapy |
|
Title
|
Primary resistance to integrase strand transfer inhibitors in Spain using ultrasensitive HIV-1 genotyping. |
|
Author
|
Casadellà M,Santos JR,Noguera-Julian M,Micán-Rivera R,Domingo P,Antela A,Portilla J,Sanz J,Montero-Alonso M,Navarro J,Masiá M,Valcarce-Pardeiro N,Ocampo A,Pérez-Martínez L,Pasquau J,Vivancos MJ,Imaz A,Carmona-Oyaga P,Muñoz-Medina L,Villar-García J,Barrufet P,Paredes R,INSTINCT Study Group. |
|
Evidence
|
Only three (1.7%) subjects had INSTI TDR (R263K, E138K and G163R), while minority variants with integrase TDR were detected in 9.6% of subjects.
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HIV Mutation Detail Information