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Mutation Information
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Mutation Site
|
E138K |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Relevant Drug
|
nevirapine (NPV) |
Literature Information
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PubMed PMID
|
32235557
|
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Published Year
|
2020 |
|
Journal
|
Molecules (Basel, Switzerland) |
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Title
|
Scaffold Hopping in Discovery of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: From CH(CN)-DABOs to CH(CN)-DAPYs. |
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Author
|
Li TT,Pannecouque C,De Clercq E,Zhuang CL,Chen FE |
|
Evidence
|
Toward the E138K mutant, compounds B3 (EC50 = 0.14 muM) and B4 (EC50 = 0.11 muM) were more potent than NVP (EC50 = 0.20 muM).
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HIV Mutation Detail Information