HIV Mutation Detail Information

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Mutation Information

Mutation Site	E138K
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT

Literature Information

PubMed PMID	32082978
Published Year	2020
Journal	Acta pharmaceutica Sinica. B
Title	Improving the positional adaptability: structure-based design of biphenyl-substituted diaryltriazines as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.
Author	Jin K,Liu M,Zhuang C,De Clercq E,Pannecouque C,Meng G,Chen F
Evidence	The modifications commonly introduced some N-containing heterocycles, including both hydrogen-bond donors and acceptors, could increase the interactions with the possible mutants, such as K103N and E138K.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation