|
Mutation Information
|
Mutation Site
|
E138K |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
NNRTIs |
Literature Information
|
PubMed PMID
|
31767136
|
|
Published Year
|
2020 |
|
Journal
|
European journal of medicinal chemistry |
|
Title
|
Indazolyl-substituted piperidin-4-yl-aminopyrimidines as HIV-1 NNRTIs: Design, synthesis and biological activities. |
|
Author
|
Xiao T,Tang JF,Meng G,Pannecouque C,Zhu YY,Liu GY,Xu ZQ,Wu FS,Gu SX,Chen FE |
|
Evidence
|
And also, it displayed potent activities against K103N (EC50=0.077muM), Y181C (EC50=0.11muM), E138K (EC50=0.057muM), and moderate activity against double mutants RES056 (EC50=8.7muM).
|
|
|
HIV Mutation Detail Information