|
Mutation Information
|
Mutation Site
|
E138K |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
IN |
|
Combined Mutation
|
in.G118R+in.E138K |
|
Genotype/Subtype
|
CRF63_02A1 |
|
Relevant Drug
|
raltegravir (RAL) |
|
Country
|
Russia |
Literature Information
|
PubMed PMID
|
31024744
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2019 |
|
Journal
|
Acta naturae |
|
Title
|
Consensus Integrase of a New HIV-1 Genetic Variant CRF63_02A1. |
|
Author
|
Agapkina YY,Pustovarova MA,Korolev SP,Zyryanova DP,Ivlev VV,Totmenin AV,Gashnikova NM,Gottikh MB |
|
Evidence
|
It was also found that the drug resistance mutations Q148K/G140S and G118R/E138K significantly reduce the catalytic activity of IN_CRF and its sensitivity to the strand transfer inhibitor raltegravir.
|
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HIV Mutation Detail Information