HIV Mutation Detail Information

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Mutation Information

Mutation Site	E138K
Mutation Type	Amino acid level
Gene/Protein/Region Type	IN
Viral Reference	K03455.1
Relevant Drug	INSTIs
Country	USA

Literature Information

PubMed PMID	30964884
Disease	HIV infection/AIDS
Published Year	2019
Journal	PloS one
Title	Validation of publicly-available software used in analyzing NGS data for HIV-1 drug resistance mutations and transmission networks in a Washington, DC, Cohort.
Author	Jair K,McCann CD,Reed H,Castel AD,Pérez-Losada M,Wilbourn B,Greenberg AE,Jordan JA,DC Cohort Executive Committee.
Evidence	These INSTI-mutations included T97A, E138A/K, Q143H, G140S and V151I. Importantly, the most common INSTI-mutation by far was E157Q;consistently present >20% (median frequency, 84.1%), but this DRM has little effect on INSTI susceptibility.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation