HIV Mutation Detail Information

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Mutation Information

Mutation Site	E138G
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Relevant Drug	NNRTIs
Country	South Africa

Literature Information

PubMed PMID	32071061
Disease	HIV infection/AIDS
Published Year	2020
Journal	Antimicrobial agents and chemotherapy
Title	Discordance between Etravirine Phenotype and Genotype-Based Predicted Phenotype for Subtype C HIV-1 from First-Line Antiretroviral Therapy Failures in South Africa.
Author	McCormick KD,Penrose KJ,Brumme CJ,Harrigan PR,Viana RV,Mellors JW,Parikh UM,Wallis CL
Evidence	Moreover, K65R was found to be associated with reduced susceptibility to ETR in genotypes that contained the NNRTI mutations V179D/F/T, Y181C/I/V, and/or M230L, whereas, no association was found with A98G, L100I, K101E/H/P, V106I, E138A/G/K/Q, or G190S/A (Table S2).

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation