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Mutation Information
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Mutation Site
|
E138G |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
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Relevant Drug
|
darunavir;cobicistat;emtricitabine (FTC);tenofovir alafenamide (TAF);tenofovir disoproxil fumarate (TDF) |
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Country
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USA |
Literature Information
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PubMed PMID
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31516033
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Disease
|
HIV infection/AIDS
|
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Published Year
|
2020 |
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Journal
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AIDS research and human retroviruses |
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Title
|
Week 48 Resistance Analyses of the Once-Daily, Single-Tablet Regimen Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide (D/C/F/TAF) in Adults Living with HIV-1 from the Phase III Randomized AMBER and EMERALD Trials. |
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Author
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Lathouwers E,Wong EY,Brown K,Baugh B,Ghys A,Jezorwski J,Mohsine EG,Van Landuyt E,Opsomer M,De Meyer S,AMBER and EMERALD Study Groups. |
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Evidence
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One participant with PDVR in the D/C/F/TAF arm had virus with one TAM, D67D/N, and one participant with PDVR in the control arm had HIV-1 with an NNRTI RAM, E138E/G, conferring resistance to rilpivirine
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HIV Mutation Detail Information