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Mutation Information
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Mutation Site
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E138E |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Relevant Drug
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abacavir (ABC);lamivudine (LAM);darunavir (DRV);ritonavir;dolutegravir (DTG);rilpivirine (RPV) |
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Country
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USA |
Literature Information
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PubMed PMID
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33941212
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Disease
|
HIV infection/AIDS
|
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Published Year
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2021 |
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Journal
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AIDS research and therapy |
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Title
|
Virologic outcomes of switching to dolutegravir functional mono- or dual therapy with a non-cytosine nucleoside analog: a retrospective study of treatment-experienced, patients living with HIV. |
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Author
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Rolle CP,Nguyen V,Hinestrosa F,DeJesus E |
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Evidence
|
Both functional monotherapy patients had a baseline HIV-1 RNA ≥ 50 copies/mL, one was switched from ABC/3TC/DRV/r to DTG/RPV (Table (Table2,2, Patient 5) and historical genotypic testing revealed an M184V/I and E138E/K which predicted that DTG was the only fully active agent in the study DCR.
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HIV Mutation Detail Information