HIV Mutation Detail Information

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Mutation Information
Mutation Site E138A
Mutation Type Amino acid level
Gene/Protein/Region Type IN
Genotype/Subtype C
Viral Reference MW690052-MW690089;  MG989443.1;  MG989444.1
Relevant Drug tenofovir (TDF);emtricitabine (FTC);darunavir (DRV);ritonavir;dolutegravir (DTG);azidothymidine (AZT);lamivudine (LAM)
Country Botswana
Literature Information
PubMed PMID 33807382
Disease HIV infection/AIDS
Published Year 2021
Journal Viruses
Title HIV-1 Subtype C Drug Resistance Mutations in Heavily Treated Patients Failing Integrase Strand Transfer Inhibitor-Based Regimens in Botswana.
Author Seatla KK,Maruapula D,Choga WT,Ntsipe T,Mathiba N,Mogwele M,Kapanda M,Nkomo B,Ramaabya D,Makhema J,Mmalane M,Mine M,Kasvosve I,Lockman S,Moyo S,Gaseitsiwe S
Evidence The four individuals failing DTG cART but with no documented prior exposure to RAL, their selected DRMs were E138K, G140A, Q148K, A128T; G118R, E138K; N155ND and T66A, G118R, E138EAKT Figure 3.

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation