Mutation Information
Mutation Site
|
E138A |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
RT |
Relevant Drug
|
NNRTIs |
Country
|
Scotland |
Literature Information
PubMed PMID
|
32877546
|
Disease
|
HIV infection/AIDS
|
Published Year
|
2020 |
Journal
|
The Journal of infectious diseases |
Title
|
From Hospital to the Community: Redesigning the Human Immunodeficiency Virus (HIV) Clinical Service Model to Respond to an Outbreak of HIV Among People Who Inject Drugs. |
Author
|
Metcalfe R,Ragonnet-Cronin M,Bradley-Stewart A,McAuley A,Stubbs H,Ritchie T,O'Hara R,Trayner K,Glover C,Laverty L,Sills L,Brown K,Gunson R,Campbell J,Milsoevic C,Anderson P,Peters SE |
Evidence
|
Phylogenetic analysis demonstrated that this strain of subtype C virus, with primary nonnucleoside reverse-transcriptase inhibitor (NNRTI) mutations E138A and V179E, had been transmitted recently and rapidly among Scottish PWID but had not yet spread anywhere else in the UK.
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