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Mutation Information
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Mutation Site
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E138A |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Relevant Drug
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darunavir;cobicistat;emtricitabine (FTC);tenofovir alafenamide (TAF);tenofovir disoproxil fumarate (TDF) |
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Country
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USA |
Literature Information
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PubMed PMID
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31516033
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Disease
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HIV infection/AIDS
|
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Published Year
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2020 |
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Journal
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AIDS research and human retroviruses |
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Title
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Week 48 Resistance Analyses of the Once-Daily, Single-Tablet Regimen Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide (D/C/F/TAF) in Adults Living with HIV-1 from the Phase III Randomized AMBER and EMERALD Trials. |
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Author
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Lathouwers E,Wong EY,Brown K,Baugh B,Ghys A,Jezorwski J,Mohsine EG,Van Landuyt E,Opsomer M,De Meyer S,AMBER and EMERALD Study Groups. |
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Evidence
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NNRTI and N(t)RTI RAMs were detected in HIV-1 of 16% and 5% of participants, respectively, with K103N and polymorphic E138E/A mutation being the most prevalent NNRTI RAMs (both 4%) and A62A/V (3%) the most prevalent N(t)RTI RAM (Table 1).
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HIV Mutation Detail Information