HIV Mutation Detail Information

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Mutation Information
Mutation Site E138A
Mutation Type Amino acid level
Gene/Protein/Region Type RT
Relevant Drug darunavir;cobicistat;emtricitabine (FTC);tenofovir alafenamide (TAF);tenofovir disoproxil fumarate (TDF)
Country USA
Literature Information
PubMed PMID 31516033
Disease HIV infection/AIDS
Published Year 2020
Journal AIDS research and human retroviruses
Title Week 48 Resistance Analyses of the Once-Daily, Single-Tablet Regimen Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide (D/C/F/TAF) in Adults Living with HIV-1 from the Phase III Randomized AMBER and EMERALD Trials.
Author Lathouwers E,Wong EY,Brown K,Baugh B,Ghys A,Jezorwski J,Mohsine EG,Van Landuyt E,Opsomer M,De Meyer S,AMBER and EMERALD Study Groups.
Evidence NNRTI and N(t)RTI RAMs were detected in HIV-1 of 16% and 5% of participants, respectively, with K103N and polymorphic E138E/A mutation being the most prevalent NNRTI RAMs (both 4%) and A62A/V (3%) the most prevalent N(t)RTI RAM (Table 1).

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation