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Mutation Information
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Mutation Site
|
E138A |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Relevant Drug
|
NNRTIs |
|
Country
|
Germany |
Literature Information
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PubMed PMID
|
30408827
|
|
Disease
|
HIV infection/AIDS
|
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Published Year
|
2018 |
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Journal
|
PloS one |
|
Title
|
Increasing proportions of HIV-1 non-B subtypes and of NNRTI resistance between 2013 and 2016 in Germany: Results from the national molecular surveillance of new HIV-diagnoses. |
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Author
|
Hauser A,Hofmann A,Meixenberger K,Altmann B,Hanke K,Bremer V,Bartmeyer B,Bannert N |
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Evidence
|
Reduced susceptibility to recommended first-line therapies was low with 1.0% for PIs, 1.3% for NRTIs and 0.7% for INSTIs, but high for the NNRTIs efavirence (4.9%) and rilpivirine (6.0%) due to the K103N mutation and the polymorphic mutation E138A.
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HIV Mutation Detail Information