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Mutation Information
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Mutation Site
|
E113D |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
E6 |
|
Combined Mutation
|
e6.L83V+e6.E113D |
|
Amino acid_Mutation
|
A442C |
|
Genotype/Subtype
|
HPV16 |
|
Viral Reference
|
NC 001526
|
|
Country
|
China |
Literature Information
|
PubMed PMID
|
27038009
|
|
Disease
|
Cervical intraepithelial neoplasia
|
|
Published Year
|
2016 |
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Journal
|
Journal of medical virology |
|
Title
|
Association between human papillomavirus type 16 E6 and E7 variants with subsequent persistent infection and recurrence of cervical high-grade squamous intraepithelial lesion after conization. |
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Author
|
Zhang L,Yang B,Zhang A,Zhou A,Yuan J,Wang Y,Sun L,Cao H,Wang J,Zheng W |
|
Evidence
|
We found that the total genetic variation was as follows: missense mutations D25E(T178G), H78Y(C335T), L83V(T350G), E113D(A442C); and synonymous mutations A131C in E6; and missense mutations A646C (N29H), A647G (N29S), synonymous mutations T846C (S95S) in E7.
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HPV Mutation Detail Information