HPV Mutation Detail Information

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Mutation Information
Mutation Site E113D
Mutation Type Amino acid level
Gene/Protein/Region Type E6
Genotype/Subtype HPV16
Country Japan
Literature Information
PubMed PMID 24150786
Disease High grade squamous intraepithelial lesion; Low grade squamous intraepithelial lesion; Cervical carcinoma
Published Year 2014
Journal Journal of medical virology
Title Functional effects of sequence variations in the E6 and E2 genes of human papillomavirus 16 European and Asian variants.
Author Hang D,Gao L,Sun M,Liu Y,Ke Y
Evidence By Western blot analysis, a similar ability to degrade p53 was observed among EUR E6, As E6, EUR E6-L83V and As E6-E113D. A rare variation, EUR E6-R10G, was found to shorten the half-life of p53 more efficiently than the other variations.

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation