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Mutation Information
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Mutation Site
|
E113D |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
E6 |
|
Amino acid_Mutation
|
A442C |
|
Genotype/Subtype
|
HPV16 |
|
Viral Reference
|
K02718.1;
NC_001526 |
|
Country
|
Morocco |
Literature Information
|
PubMed PMID
|
23953248
|
|
Disease
|
Cervical carcinoma
|
|
Published Year
|
2013 |
|
Journal
|
BMC infectious diseases |
|
Title
|
Analysis of mutations in the E6 oncogene of human papillomavirus 16 in cervical cancer isolates from Moroccan women. |
|
Author
|
Qmichou Z,Khyatti M,Berraho M,Ennaji MM,Benbacer L,Nejjari C,Benjaafar N,Benider A,Attaleb M,El Mzibri M |
|
Evidence
|
The most prevalent non-synonymous variants were L83V (T350G), H78Y (C335T), E113D (A442C) and Q14D (C143G/G145T) and were observed respectively in 65%, 41.8%, 38.8% and 30.1% of total samples. The other non-synonymous variants were R10I (G132T), R10G (A131G), D64E (T295G), Q14H (G145T) and A61G (C285G) and were seen in 23.3%, 6.8%, 6.8%, 1.9% and 1% of cases respectively.
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HPV Mutation Detail Information