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Mutation Information
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Mutation Site
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E102A |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Gp120 |
Literature Information
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PubMed PMID
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23011758
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Published Year
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2013 |
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Journal
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Proteins |
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Title
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HIV-1 Env gp120 structural determinants for peptide triazole dual receptor site antagonism. |
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Author
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Tuzer F,Madani N,Kamanna K,Zentner I,LaLonde J,Holmes A,Upton E,Rajagopal S,McFadden K,Contarino M,Sodroski J,Chaiken I |
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Evidence
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Of these mutants, the following were chosen for a more detailed screen of KR21's affinity and inhibitory potency on them: K97A, E102A and R476A since these mutations affected inhibition by the original peptide 12p1 and showed differences with WT in the ELISA screen (see Fig.
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HIV Mutation Detail Information