HPV Mutation Detail Information

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Mutation Information

Mutation Site	D86E
Mutation Type	Amino acid level
Gene/Protein/Region Type	E6
Genotype/Subtype	HPV58
Viral Reference	NC_001443.1

Literature Information

PubMed PMID	23136059
Disease	Low grade squamous intraepithelial lesion; High grade squamous intraepithelial lesion; Cervical carcinoma
Published Year	2013
Journal	International journal of cancer
Title	Geographical distribution and oncogenic risk association of human papillomavirus type 58 E6 and E7 sequence variations.
Author	Chan PK,Zhang C,Park JS,Smith-McCune KK,Palefsky JM,Giovannelli L,Coutlée F,Hibbitts S,Konno R,Settheetham-Ishida W,Chu TY,Ferrera A,Alejandra Picconi M,De Marco F,Woo YL,Raiol T,Piña-Sánchez P,Bae JH,Wong MC,Chirenje MZ,Magure T,Moscicki AB,Fiander AN,Capra G,Young Ki E,Tan Y,Chen Z,Burk RD,Chan MC,Cheung TH,Pim D,Banks L
Evidence	Africa had significantly more isolates with E6-367A (D86E) but significantly less isolates with E6-203G, -245G, -367C (prototype-like) than other regions (p <= 0.003).

Contents
Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation