|
Mutation Information
|
Mutation Site
|
D67N |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
NRTIs |
|
Country
|
UK |
Literature Information
|
PubMed PMID
|
30409215
|
|
Clinical information
|
Yes
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2018 |
|
Journal
|
AIDS research and therapy |
|
Title
|
Characterization of minority HIV-1 drug resistant variants in the United Kingdom following the verification of a deep sequencing-based HIV-1 genotyping and tropism assay. |
|
Author
|
Silver N,Paynter M,McAllister G,Atchley M,Sayir C,Short J,Winner D,Alouani DJ,Sharkey FH,Bergefall K,Templeton K,Carrington D,Quiñones-Mateu ME |
|
Evidence
|
The most prevalent primary minority drug resistance mutations observed in both cohorts of patients were the PIs M46I/L (in 3 and 9 SG and NHS individuals, respectively) and I50 V (2 and 5);the NRTIs D67N (23 and 20), K65R (0 and 9), L74I (2 and 0), M184V/I (6 and 0) and K219Q (9 and 10);and the NNRTI L100I (6 and 3).
|
|
|
HIV Mutation Detail Information