Mutation Information
Mutation Site
|
D67N |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
RT |
Literature Information
PubMed PMID
|
18547911
|
Published Year
|
2008 |
Journal
|
The Journal of biological chemistry |
Title
|
Connection domain mutations N348I and A360V in HIV-1 reverse transcriptase enhance resistance to 3'-azido-3'-deoxythymidine through both RNase H-dependent and -independent mechanisms. |
Author
|
Ehteshami M,Beilhartz GL,Scarth BJ,Tchesnokov EP,McCormick S,Wynhoven B,Harrigan PR,Götte M |
Evidence
|
Furthermore, A360V was highly correlated with various mutations considered to be part of the TAMs cluster;for example, of the samples with A360V, 35% were associated with M41L, 21% with D67N, 30% with K70R, 17% with L210W, 42% with T215Y/F, and 17% with K219Q/E.
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