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Mutation Information
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Mutation Site
|
D474A |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
Gp120 |
Literature Information
|
PubMed PMID
|
23011758
|
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Published Year
|
2013 |
|
Journal
|
Proteins |
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Title
|
HIV-1 Env gp120 structural determinants for peptide triazole dual receptor site antagonism. |
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Author
|
Tuzer F,Madani N,Kamanna K,Zentner I,LaLonde J,Holmes A,Upton E,Rajagopal S,McFadden K,Contarino M,Sodroski J,Chaiken I |
|
Evidence
|
Two mutations, D474A and T257A, caused large-scale loss of KR21 binding, as well as losses in both CD4/17b and viral inhibition by KR21.
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HIV Mutation Detail Information