|
Mutation Information
|
Mutation Site
|
D45E |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
E1^E4 |
|
Amino acid_Mutation
|
C3476A;C3476T |
|
Genotype/Subtype
|
HPV16 |
|
Viral Reference
|
NC_ 001526
|
|
Country
|
Greece |
Literature Information
|
PubMed PMID
|
22684534
|
|
Disease
|
Cervical intraepithelial neoplasia
|
|
Published Year
|
2012 |
|
Journal
|
Archives of virology |
|
Title
|
Molecular and phylogenetic analysis of the HPV 16 E4 gene in cervical lesions from women in Greece. |
|
Author
|
Tsakogiannis D,Ruether IG,Kyriakopoulou Z,Pliaka V,Skordas V,Gartzonika C,Levidiotou-Stefanou S,Markoulatos P |
|
Evidence
|
In addition, nine amino acid mutations (A7V, A7P, L16I, D45E, L59I, L59T, Q66P, S72F, H75Q) were detected in the E1( )E4 protein, and these were associated with the severity of cervical malignancy.
|
|
|
HPV Mutation Detail Information