HIV Mutation Detail Information

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Mutation Information

Mutation Site	D37A
Mutation Type	Amino acid level
Gene/Protein/Region Type	Vif
Combined Mutation	vif.W38A+vif.D37A

Literature Information

PubMed PMID	28302150
Published Year	2017
Journal	Retrovirology
Title	Identification of a tripartite interaction between the N-terminus of HIV-1 Vif and CBFβ that is critical for Vif function.
Author	Desimmie BA,Smith JL,Matsuo H,Hu WS,Pathak VK
Evidence	Vif mutants W5A-Q6A, H27A-H28A, D37A-W38A, T47A-N48A, P49A-K50A, and I51A-S52A exhibited significant defects in their ability to mediate A3G degradation compared to WT Vif (Fig. 2b, c). ;Notably, of the mutants examined, W5A-Q6A, I9A-V10A, H27A-H28A, and D37A-W38A significantly reduced Vif’s ability to bind to CBFβ compared to WT Vif (Fig. 1b; values indicated in green).

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation