Mutation Information
Mutation Site
|
D325S |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
Env |
Viral Reference
|
K03455.1
|
Immune Escape
|
Y |
Literature Information
PubMed PMID
|
30709739
|
Published Year
|
2019 |
Journal
|
Immunity |
Title
|
An Antigenic Atlas of HIV-1 Escape from Broadly Neutralizing Antibodies Distinguishes Functional and Structural Epitopes. |
Author
|
Dingens AS,Arenz D,Weight H,Overbaugh J,Bloom JD |
Evidence
|
For example, mutations at site 325 had disparate effects: D325E had a large effect on 10-1074 but a negligible effect PGT121, D325S had a small effect for 10-1074 but no effect for PGT121, and D325N had no effect on either antibody (Figure 3A,B and validated in Figure S3).
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