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Mutation Information
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Mutation Site
|
D30N |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Genotype/Subtype
|
A1 |
|
Relevant Drug
|
NNRTIs;PIs |
|
Country
|
Kenya |
Literature Information
|
PubMed PMID
|
30759103
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2019 |
|
Journal
|
PloS one |
|
Title
|
Presence, persistence and effects of pre-treatment HIV-1 drug resistance variants detected using next generation sequencing: A Retrospective longitudinal study from rural coastal Kenya. |
|
Author
|
Hassan AS,Bibby DF,Mwaringa SM,Agutu CA,Ndirangu KK,Sanders EJ,Cane PA,Mbisa JL,Berkley JA |
|
Evidence
|
Overall, 15 mutations (frequency, range: 2.3-92.0%) were detected conferring reduced susceptibility to PIs (n = 7), NRTIs (n = 4) and NNRTIs (n = 4), with the most common being the PIs-associated D30N (n = 2) and the NNRTIs-associated G190A (n = 2). Only one participant had dual class resistance with mutations against both NRTIs (D67G) and NNRTIs (V106IM).
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HIV Mutation Detail Information