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Mutation Information
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Mutation Site
|
D25N |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
E6 |
|
Amino acid_Mutation
|
G176A |
|
Genotype/Subtype
|
HPV16 |
|
Viral Reference
|
K02718.1;
NC_001526 |
|
Country
|
Poland |
Literature Information
|
PubMed PMID
|
27801430
|
|
Disease
|
Cervical carcinoma;
Low grade squamous intraepithelial lesion
|
|
Published Year
|
2017 |
|
Journal
|
Acta biochimica Polonica |
|
Title
|
HPV16 E6 polymorphism and physical state of viral genome in relation to the risk of cervical cancer in women from the south of Poland. |
|
Author
|
Szostek S,Zawilinska B,Klimek M,Kosz-Vnenchak M |
|
Evidence
|
Sequence analysis of 80 studied samples showed substitutions in 9 nucleotides located between positions 122 and 350 (G122A, T137G, G145T, C153T, G176A, G188A, T295G, C335T, T350G) leading to the amino acid change (E7K, L12V,Q14H, T17I, D25N, E29K, D64E, H78Y, L83V) while other nucleotide substitutions (T109C, C256T, T286A, A289G) were silent.
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HPV Mutation Detail Information