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Mutation Information
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Mutation Site
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D25A |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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PR |
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Relevant Drug
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PIs |
Literature Information
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PubMed PMID
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16956392
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Published Year
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2006 |
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Journal
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Retrovirology |
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Title
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HIV-2 Protease resistance defined in yeast cells. |
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Author
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M'Barek NB,Audoly G,Raoult D,Gluschankof P |
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Evidence
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The galactose induced cell death was found to be directly linked to the protease enzyme activity, since when the Asp residue of the active site of the viral enzyme was modified to Ala (D25A mutant), the inactive Protease expressed in transformed cells (Fig 1C, lane 3) did not induce cell death when grown on galactose (Fig 1B).
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HIV Mutation Detail Information