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Mutation Information
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Mutation Site
|
D186N |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
|
Country
|
Nicaragua;Israel;Switzerland;France;US;Japan;Ethiopia |
Literature Information
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PubMed PMID
|
32102090
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2020 |
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Journal
|
PloS one |
|
Title
|
Analysis of unusual and signature APOBEC-mutations in HIV-1 pol next-generation sequences. |
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Author
|
Tzou PL,Kosakovsky Pond SL,Avila-Rios S,Holmes SP,Kantor R,Shafer RW |
|
Evidence
|
Active site mutations in PR (D25N), RT (D110N, D185N, and D186N), and IN (D64N, D116N, and E152K) result from APOBEC3F editing of aspartic acid GAC/T (D) → AAC/T (N) or glutamic acid GAA/G (E) → AAA/G (K).
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HIV Mutation Detail Information