Mutation Information
Mutation Site
|
D185N |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
Gp120 |
Viral Reference
|
K03455.1
|
Literature Information
PubMed PMID
|
24758333
|
Published Year
|
2014 |
Journal
|
Retrovirology |
Title
|
Impact of amino acid substitutions in the V2 and C2 regions of human immunodeficiency virus type 1 CRF01_AE envelope glycoprotein gp120 on viral neutralization susceptibility to broadly neutralizing antibodies specific for the CD4 binding site. |
Author
|
Utachee P,Isarangkura-na-ayuthaya P,Tokunaga K,Ikuta K,Takeda N,Kameoka M |
Evidence
|
In addition, the introduction of a mutation, D185N or D185E, altered the b12 susceptibility of selected AE-Env clones, 29CC1, 45CC1, 47PL1, 105PB1 and 105PL3, to a lesser extent than the alteration by the introduction of D185G to the corresponding AE-Env clones (Table 5).
|
|
|