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Mutation Information
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Mutation Site
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D185E |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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RT |
Literature Information
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PubMed PMID
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32852081
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Published Year
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2020 |
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Journal
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The EMBO journal |
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Title
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Disrupting HIV-1 capsid formation causes cGAS sensing of viral DNA. |
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Author
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Sumner RP,Harrison L,Touizer E,Peacock TP,Spencer M,Zuliani-Alvarez L,Towers GJ |
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Evidence
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We conclude that viral DNA is the active PAMP and this notion was also supported by the observation that mutation D185E in the RT active site (HIV-1 CA-SP1 RT D185E) also reduced activation of IFIT-1 luc expression (Fig 3E) and CXCL10 secretion (Fig 3F) on infection of the THP-1 IFIT-1 reporter cells.
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HIV Mutation Detail Information