EBV Mutation Detail Information

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Mutation Information

Mutation Site	D150A
Mutation Type	Amino acid level
Gene/Protein/Region Type	LMP1

Literature Information

PubMed PMID	21560118
Published Year	2011
Journal	Biopolymers
Title	Transmembrane peptides used to investigate the homo-oligomeric interface and binding hotspot of latent membrane protein 1.
Author	Sammond DW,Joce C,Takeshita R,McQuate SE,Ghosh N,Martin JM,Yin H
Evidence	Replacement of this aspartic acid residue with alanine disrupts TM5 self-association in detergent micelles and bacterial cell membranes. A full length LMP-1 variant harboring the D150A substitution is deficient in NFkappaB activation, supporting the key role of the fifth transmembrane helix in constitutive activation of signaling by this oncoprotein.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation