|
Mutation Information
|
Mutation Site
|
D144G |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Genotype/Subtype
|
A |
|
Immune Escape
|
Y |
|
Relevant Drug
|
hepatitis B immunoglobulin (HBIG) |
Literature Information
|
PubMed PMID
|
14756274
|
|
Disease
|
Chronic hepatitis B;
Hepatocellular carcinoma
|
|
Published Year
|
2003 |
|
Journal
|
Clinical transplantation |
|
Title
|
Efficacy of combined lamivudine and adefovir dipivoxil treatment for severe HBV graft reinfection after living donor liver transplantation. |
|
Author
|
Beckebaum S,Malagó M,Dirsch O,Cicinnati VR,Trippler M,Lampertico P,Lama N,Treichel U,Gerken G,Broelsch CE |
|
Evidence
|
Hepatitis B virus sequence analysis revealed several mutations in the polymerase gene (L528M, M552I, M552V) as well as in the surface gene region encoding the immunogenic major hydrophilic loop of the small surface protein (G130N, M133T, D144G).
|
|
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HBV Mutation Detail Information