|
Mutation Information
|
Mutation Site
|
D144E |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Combined Mutation
|
s.D144E+s.K122R;s.D144E+s.C121R+s.K122R;s.D144E+s.F134L+s.K122R |
|
Country
|
china |
Literature Information
|
PubMed PMID
|
32763811
|
|
Disease
|
Occult HBV infection
|
|
Published Year
|
2020 |
|
Journal
|
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology |
|
Title
|
The sK122R mutation of hepatitis B virus (HBV) is associated with occult HBV infection: Analysis of a large cohort of Chinese patients. |
|
Author
|
Wang J,Liu Y,Liao H,Liu L,Chen R,Si L,Luo D,Huang B,Li L,Jiang J,Xu D |
|
Evidence
|
The patient was treated with IFN-α+lamivudine, and sK122R-containing mutants persisted during the observation period. Specifically, sK122R, sK122R + D144E, sK122R + C121R + D144E, and sK122R + F134L + D144E mutants respectively comprised 86.4 %, 4.5 %, 4.5 %, and 4.5 % of tested viral clones at the first time-point (sample 1). ;After 4 months of treatment, the sK122R and sK122R + sD144E mutants respectively comprised 95.2 % and 4.8 % of the viral clones in sample 2. ;Five viral strains from patient 1, wild-type (WT), sK122R (M1), sK122R + D144E (M2), sK122R + C121R + D144E (M3), and sK122R + F134L + D144E (M4), were transfected into HepG2 cells, and HBV DNA levels were determined in the culture supernatant after 72 h.;Five viral strains from patient 1, wild-type (WT), sK122R (M1), sK122R + D144E (M2), sK122R + C121R + D144E (M3), and sK122R + F134L + D144E (M4), were transfected into HepG2 cells, and HBV DNA levels were determined in the culture supernatant after 72 h.
|
|
|
HBV Mutation Detail Information