|
Mutation Information
|
Mutation Site
|
D144E |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Combined Mutation
|
s.G145R+s.D144E |
|
Genotype/Subtype
|
D |
|
Immune Escape
|
Y |
|
Relevant Drug
|
tenofovir (TDF);rituximab;fludarabine |
|
Country
|
Germany |
Literature Information
|
PubMed PMID
|
23679074
|
|
Disease
|
HBV infection
|
|
Published Year
|
2013 |
|
Journal
|
BMC infectious diseases |
|
Title
|
Late HBsAg seroreversion of mutated hepatitis B virus after bone marrow transplantation. |
|
Author
|
Schubert A,Michel D,Mertens T |
|
Evidence
|
Despite living without immunosuppressive agents for more than 40 months, she developed a fulminant HBV infection with detection of a mutated hepatitis B virus carrying two immune escape mutations (D144E/G145R) in the HBsAg (HBsIE mutation).
|
|
|
HBV Mutation Detail Information