|
Mutation Information
|
Mutation Site
|
D144E |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Genotype/Subtype
|
C |
|
Immune Escape
|
Y |
|
Relevant Drug
|
hepatitis B immunoglobulin (HBIG);lamivudine (LAM) |
|
Country
|
korea |
Literature Information
|
PubMed PMID
|
12966541
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2003 |
|
Journal
|
Journal of medical virology |
|
Title
|
Evolution of hepatitis B virus sequence from a liver transplant recipient with rapid breakthrough despite hepatitis B immune globulin prophylaxis and lamivudine therapy. |
|
Author
|
Kim KH,Lee KH,Chang HY,Ahn SH,Tong S,Yoon YJ,Seong BL,Kim SI,Han KH |
|
Evidence
|
These mutations caused L426I/L526M/M550I triple mutation (equivalent to L428I/L528M/M552I in previous reports) in the polymerase, and D144E mutation in the "a" determinant of HBsAg.
|
|
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HBV Mutation Detail Information