|
Mutation Information
|
Mutation Site
|
D144E |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Combined Mutation
|
s.G145R+s.D144E |
Literature Information
|
PubMed PMID
|
11886250
|
|
Published Year
|
2002 |
|
Journal
|
Virology |
|
Title
|
Reduced antigenicity of the hepatitis B virus HBsAg protein arising as a consequence of sequence changes in the overlapping polymerase gene that are selected by lamivudine therapy. |
|
Author
|
Torresi J,Earnest-Silveira L,Deliyannis G,Edgtton K,Zhuang H,Locarnini SA,Fyfe J,Sozzi T,Jackson DC |
|
Evidence
|
HBsAg proteins containing the vaccine escape mutations G145R and D144E/G145R demonstrated markedly reduced binding to anti-HBs antibody.
|
|
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HBV Mutation Detail Information