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Mutation Information
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Mutation Site
|
D144E |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
S |
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Genotype/Subtype
|
Adw2 |
Literature Information
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PubMed PMID
|
10385663
|
|
Disease
|
HBV infection
|
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Published Year
|
1999 |
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Journal
|
Hepatology (Baltimore, Md.) |
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Title
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Mutational pattern of hepatitis B virus on sequential therapy with famciclovir and lamivudine in patients with hepatitis B virus reinfection occurring under HBIg immunoglobulin after liver transplantation. |
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Author
|
Tillmann HL,Trautwein C,Bock T,Böker KH,Jäckel E,Glowienka M,Oldhafer K,Bruns I,Gauthier J,Condreay LD,Raab HR,Manns MP |
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Evidence
|
These mutations were a G145Rmutation associated with a D144E mutation of the HBsAg corresponding to aW501E mutantof the HBV-DNA polymer-ase in 2 patients (R01, NR22), and a P120T mutation corresponding to a T476N mutation of the HBV-DNA polymerase in 6 (R01, PR11, NR24, PR 16, PR19, NR26), of whom 1(R01) also had the G145R and D144E mutations
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HBV Mutation Detail Information