Mutation Information
Mutation Site
|
D144A |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
S |
Country
|
China |
Literature Information
PubMed PMID
|
22634131
|
Disease
|
Occult HBV infection
|
Published Year
|
2012 |
Journal
|
Journal of hepatology |
Title
|
Influence of mutations in hepatitis B virus surface protein on viral antigenicity and phenotype in occult HBV strains from blood donors. |
Author
|
Huang CH,Yuan Q,Chen PJ,Zhang YL,Chen CR,Zheng QB,Yeh SH,Yu H,Xue Y,Chen YX,Liu PG,Ge SX,Zhang J,Xia NS |
Evidence
|
Four out of the 13 mutations (C124R, C124Y, K141E, and D144A) strongly decreased the analytical sensitivity of seven commercial HBsAg immunoassays, and 10 (G119R, C124Y, I126S, Q129R, S136P, C139R, T140I, K141E, D144A, and G145R) significantly impaired virion and/or S protein secretion in both HuH7 cells and mice.
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