|
Mutation Information
|
Mutation Site
|
D144A |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Combined Mutation
|
s.L209V+s.D144A |
|
Genotype/Subtype
|
E |
|
Immune Escape
|
Y |
|
Country
|
Argentine |
Literature Information
|
PubMed PMID
|
16954295
|
|
Disease
|
HBV infection
|
|
Published Year
|
2006 |
|
Journal
|
Journal of clinical microbiology |
|
Title
|
Detection of hepatitis B virus (HBV) genotype E carried--even in the presence of high titers of anti-HBs antibodies--by an Argentinean patient of African descent who had received vaccination against HBV. |
|
Author
|
Mathet VL,Cuestas ML,Ruiz V,Minassian ML,Rivero C,Trinks J,Daleoso G,León LM,Sala A,Libellara B,Corach D,Oubiña JR |
|
Evidence
|
One of them (who had been vaccinated against HBV) exhibited anti-HBs cocirculating antibodies without HBsAg escape mutants, while her unvaccinated sister showed a D144A HBsAg escape mutant without anti-HBs antibodies. Both sisters carried an unusual L209V substitution within HBsAg.
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HBV Mutation Detail Information