Mutation Information
Mutation Site
|
D116A |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
IN |
Literature Information
PubMed PMID
|
19014595
|
Published Year
|
2008 |
Journal
|
Retrovirology |
Title
|
Contribution of the C-terminal region within the catalytic core domain of HIV-1 integrase to yeast lethality, chromatin binding and viral replication. |
Author
|
Xu Z,Zheng Y,Ao Z,Clement M,Mouland AJ,Kalpana GV,Belhumeur P,Cohen EA,Yao X |
Evidence
|
Previous studies have indicated that the catalytic activity of IN may be required for IN-induced lethality in yeast since introduction of an IN catalytic mutant (D116A) was not lethal in the yeast strain AB2.
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