HBV Mutation Detail Information

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Mutation Information

Mutation Site	C69*
Mutation Type	Amino acid level
Gene/Protein/Region Type	S
Country	Italy

Literature Information

PubMed PMID	23796863
Disease	HBV infection
Published Year	2013
Journal	The Journal of infection
Title	Anti-HBV treatment induces novel reverse transcriptase mutations with reflective effect on HBV S antigen.
Author	Cento V,Van Hemert F,Neumann-Fraune M,Mirabelli C,Di Maio VC,Salpini R,Bertoli A,Micheli V,Gubertini G,Romano S,Visca M,De Sanctis GM,Berkhout B,Marino N,Mazzotta F,Cappiello G,Spanò A,Sarrecchia C,Ceccherini-Silberstein F,Andreoni M,Angelico M,Verheyen J,Perno CF,Svicher V
Evidence	Moreover, rtS78T introduced a stop-codon at HBsAg-position 69, and completely abrogated HBsAg-quantification in both supernatants and cell-lysates, indicating an impaired HBsAg-secretion/production.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation