Mutation Information
Mutation Site
|
C6460G |
Mutation Type
|
Nucleotide level |
Gene/Protein/Region Type
|
L1 |
Nucleotide_Mutation
|
P344R |
Genotype/Subtype
|
HPV18 |
Viral Reference
|
NC_001357.1
|
Country
|
China |
Literature Information
PubMed PMID
|
23451059
|
Disease
|
Cervical carcinoma
|
Published Year
|
2013 |
Journal
|
PloS one |
Title
|
Sequence variation analysis of HPV-18 isolates in southwest China. |
Author
|
Shen M,Ding X,Li T,Chen G,Zhou X |
Evidence
|
DNA sequence analysis of the HPV-18 L1 region revealed six variations: a G to A transition at nt5503, leading to a R25Q AA substitution (n = 23, 41.1%) (Fig. 1I); a C to G transversion at nt5701 with an AA change of P91R (n = 23, 41.1%) (Fig. 1J); a C to G transversion at nt6460 with an AA change of P344R (n = 24, 42.9%) (Fig. 1K); a C to G transversion at nt6625 with an AA change of P399R (n = 25, 44.6%) (Fig. 1L); a C to G transversion at nt6842 with an AA change of P471R (n = 23, 41.1%) (Fig. 1M); and G to A transition at nt6906 with an AA change of D493N (n = 12, 21.4%) (Fig. 1N).
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