HIV Mutation Detail Information

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Mutation Information

Mutation Site	C604S
Mutation Type	Amino acid level
Gene/Protein/Region Type	Env
Viral Reference	AAB50262.1

Literature Information

PubMed PMID	31504041
Published Year	2019
Journal	PloS one
Title	Identification of variant HIV envelope proteins with enhanced affinities for precursors to anti-gp41 broadly neutralizing antibodies.
Author	Zhu H,Mathew E,Connelly SM,Zuber J,Sullivan M,Piepenbrink MS,Kobie JJ,Dumont ME
Evidence	Combination of the three most abundant substitutions (W631R, C605R, and W623R) with five additional mutations recovered in individual sorted variants (L545H, L566Q, C604S, A612T, and I642N) resulted in a form of Env that bound to the 4E10 UCA with higher affinity than any other tested variant (Fig 1F, Table 3).

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation